Ninety-two thousand more people in the U.S. could die of COVID-19 in the next three weeks, according to a grim forecast issued by the Centers for Disease Control and Prevention. Another 3,800 deaths were reported Wednesday, and over 225,000 new confirmed cases. Over 130,000 people are hospitalized with COVID-19.

Pennsylvania said its number of hospitalizations is now close to double the peak of the spring’s first wave. Arizona officials also reported record-high hospitalization and ICU numbers this week. A staggering one in three Los Angeles County residents has gotten the coronavirus since the start of the pandemic, according to new data.

Early trials for Johnson & Johnson’s experimental coronavirus vaccine are showing promising results. If further trials prove effective, the vaccine could be a game-changer as it requires just one shot and does not need to be stored in ultra-cold freezers.