Germany’s vice chancellor says that talks aimed at forging a massive trade agreement between the U.S. and the European Union have failed. Sigmar Gabriel, who also serves as Germany’s economy minister, said Sunday that the stalemate could spell the end of the proposed Transatlantic Trade and Investment Partnership, or TTIP, which would be the largest free trade agreement in the world. It’s faced massive resistance on both sides of the Atlantic, including a 35,000-person protest in Germany ahead of Obama’s visit in April.