In South Dakota, the Centers for Disease Control and Prevention is investigating one of the largest pork processing plants in the world, where cases of COVID-19 related to the factory have surged to at least 730. The Smithfield plant in Sioux Falls is now the biggest single coronavirus hot spot in the United States. The mayor of Sioux Falls has ordered residents to shelter in place, after Republican Governor Kristi Noem refused to issue a statewide remain-at-home order.